husband is diagnosis's with depression and some anxiety. 2 years ago, he was given Wellbutrin first, made him feel "higher than a kite" so we tried Lexapro, he said made his head feel in the clouds and dizzy, he couldn't deal with that, so he stopped after 3 weeks, I could tell a difference but he couldn't work and deal with that feeling, but gave him agitation during sleep and awake really. 1 yr later we tried St. Johns wort, no side effects but didn't help. Due to his anger issues, mood swings, depression, agitation, extreme HIGH blood pressure she wants him on something to calm him. So we tried Zoloft, he said again, head in the clouds. He can't take anything, it's weird, Benadryl instead of making him sleep he will become agitated and annoyed, can't sleep for hours, gives him rapid heart rates and everything. So now she RX'd him Effexor XR but I never heard of this one. Anyone have any other ideas or advice on how patients like this can be treated. We are really desperate and I'm scared nothing will work for him.