My son has been on Seroquel for the last 4 years, and we just had to take him off of it due to him having some abberrant muscle problems related to the Seroquel. During his time on Seroquel he, of course, had the usual appetite increase, but it was not as bad as when he was on Risperdal. About a year ago, he had his cholesterol taken, and to our surprise we found out it was 600!!!! The doctor sent him to a cardiologist, and she and I worked on an extensive program to get his cholsterol lowered. She was fearful that with cholestrol this high he could get pancreatitis. Anyway, to make a long story short, neither the cardiologist, or psychiatrist mentioned that this can be a side effect of Seroquel!!! Fast forward to a month ago, his cholestrol was down to 400, but still high, and his glucose was high. He also developed this weird muscle problem so we abruptly took him off of the Seroquel. Within a week his cholestrol was already down to normal, and he lost 14 pounds!!!! It was a shocking revelation!!!! No one had ever related the Seroquel to his glucose or cholestrol until I took him off of it! Man, truthfully, I was a bit steamed that this was not caught sooner! Both docs just blamed genetics. When I looked up Seroquel on the internet recently, and found all of the class action law suits against the makers of Seroquel - guess what the 2 things they are suing for? That Seroquel caused patients pancreatitis (due to high cholestrol), and diabetes! In fact a person on Seroquel is 3.3 times more likely to develop diabetes than someone who is not on it I found out. Anyway - I say all of this to just make sure that those of you with kids on Seroquel have their cholestrol and glucose checked regularly. Obviously it does not seem that some psychiatrists have this on their list of bloodwork that has to be done with this medication - but in my opinion, it is a must.